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Chicken heart citrate synthase: some mechanism studies

✍ Scribed by Sonia Beeckmans; Louis Kanarek


Book ID
103115606
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
964 KB
Volume
15
Category
Article
ISSN
0020-711X

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Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis. The rapid reaction rate is puzzling because of the instability of the postulated nucleophilic intermediate, the enolate of acetyl-CoA. As altern