Chest radiograph—A poor method for determining the size of a pneumothorax: Engdahl O, Toft T, Boe J Chest 103:26–29 Jan 1993
✍ Scribed by Michael Dolister
- Book ID
- 104311312
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 111 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1097-6760
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✦ Synopsis
This prospective study examined 252 pregnant women with gonorrhea to determine the efficacy of 1989 Centers for Disease Control recommendations for treatment of gonorrhea in pregnancy. Many studies are available that demonstrate the efficacy of this regimen in nonpregnant patients, but there are few on efficacy in pregnant patients. Pretreatment endocervical, rectal, and oral cultures for Neisseria gonorrhoeae and direct fluorescent antibody testing for Chlamydia trachomatis wer e performed. Patients were randomly assigned t o receive 250 mg ceftriaxone IM, 2 g spectinomycin IM, or 3 g amoxicillin plus 1 g probenecid orally. Two hundred forty-five women (97%)had endocervical infection, 68 (27%)had rectal infection, and 17 (7%) had pharyngeal infection. Forty percent of the 252 patients had concomitant C trachomatis. Ceftriaxone Was effective in 80 of 84 cases (95%), spectinomycin was effective in 80 of 84 cases (95%), and amoxicillin with probenecid was effective in 75 of 84 cases (89%). No significant difference was noted in overall efficacy or by site of infection. The authors conclude that both ceftriaxone and spectinomycin are effective for the treatment of gonorrhea in pregnancy. Although not statistically significant, amexicillin with probenecid had a lower efficacy than ceftriaxone or spectinomycin. Accordinq to the authors, the failure to achieve a standard of 95% efficacy with 90% reliability and the particularly poor rate of cure with rectal infection make this regimen a poor choice for treatment of gonorrhea in pregnancy.