Abshct Spceimests ofAosonacherimola(Atrssonaeeae ) fium Taiwan emrtainedcherimotine(l), which waaide.ntifkdby arralysisof spectd datil. 0 1997Elsevier Science Ltd.
AMtoughAtmonaeemtsaectogeninsconstitute the majorityof mthtmtproductsfrom Atmonaeae of Taiwan,' a large but sk@fs-t nmn~r of Woids hve been described. TISCSS include oxoapo@nes,2 apot@rin=.3 Ircsrzylimqsdstoiines."J proapmphines.5phenanthmne aikaloids..c and some amides.'As part of our corrdmring investigationon the akatoids of ForsnosatsAnnossaeeous plant.%we have isolatedscvemtalkaloidsfrom the methanolatemextraet ofAmona cherinroIa. Among them. the cherimoline (1). prcaent a novel strrreturcin which the 6-memberedIaetone quistotirretype. We rcprt herein the stmetural elucidationof 1.
Specimens of the A cherimola were collected from Chia-Yi. Taiwan, Septcmber1995. It is a subtropieat tit tree etdtivated in southern Taiwan, which is indigenousto Ecuador and Pem. It has bermoacd for the treatment of akin diacase.
e-i@ for ~il in fo~m~citte.s me me~ol e-wss xtedby rwemcd and nommJphase chromatography toobtain a fmetion with a signitieant 'H NMR spectmm. Ptsri6eation by TLC on silica using 20:1 CHC13fMeOH as elwcnt gave cherimoline(1. 0.003% dry wt.).
Cherimoline(l), waa obtainedas a white pwdcr, mp 203-205'C. The mokeuk formula, C12H7N02,