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Chemotherapy of the squamous cell lung cancer LC-12 with 5-fluorouracil, cisplatin, carboplatin or iproplatin combinations

✍ Scribed by Efstathios Tapazoglou; Lisa Polin; Thomas H. Corbett; Muhyi Al-Sarraf

Publisher: Springer US
Year: 1988
Tongue: English
Weight: 403 KB
Volume: 6
Category: Article
ISSN: 0167-6997
DOI: 10.1007/bf00173643

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✦ Synopsis

The combination of Cis-dichlorodiammineplatinum (II) (CisDDPt) + 5-Fluorouracil (5-FU) was compared with two CisDDPt analogues + 5-FU [Iproplatin (CHIP) + 5-FU and Carboplatin (CBDCA) + 5-FU] for relative efficacy against advanced stage squamous cell lung tumors (LC-12) in Balb/c mice. At equitoxic dosages, the numbers of regressions and cures were similar for the three combinations (5-

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