Chemotherapy is a safe and effective initial therapy for infected malignant breast and chest wall ulcers
✍ Scribed by Dauphin, Serge; Katz, Steven; El Tamer, Mahmoud; Wait, Richard; Sohn, Chul; Braverman, Albert S.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 20 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background and Objectives: Locally advanced breast cancers may form large, infected skin ulcers, which were traditionally treated with radiation therapy. Neoadjuvant chemotherapy is now standard treatment for locally advanced breast cancer. Methods: The response of 33 patients with ulcerated breast cancer to primary chemotherapy was retrospectively analyzed. Antibiotics were not used in primary treatment. Tumor and ulcer responses were evaluated independently. Results: Chemotherapy alone healed 18 of these ulcers. Neither responding nor refractory patients developed sepsis during this treatment. Conclusions: Chemotherapy is safe and effective treatment for patients with infected malignant breast ulcers and does not cause systemic sepsis.