Chemotherapeutic and potential synergistic effects of gynostemma pentaphyllum with 5-fluorouracil in Apcmin/+ colorectal cancer mouse model

Synergistic antitumor activity of the no

Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

✍ Takako Eguchi Nakajima; Masahiro Yasunaga; Yasuhiko Kano; Fumiaki Koizumi; Ken K 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 598 KB

## Abstract The authors reported in a previous study that NK012, a 7‐ethyl‐10‐hydroxy‐camptothecin (SN‐38)‐releasing nano‐system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochlori