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Chemotherapeutic activity of silymarin combined with doxorubicin or paclitaxel in sensitive and multidrug-resistant colon cancer cells

✍ Scribed by Valentina Colombo; Monica Lupi; Francesca Falcetta; Daniele Forestieri; Maurizio D’Incalci; Paolo Ubezio


Publisher
Springer
Year
2010
Tongue
English
Weight
512 KB
Volume
67
Category
Article
ISSN
0344-5704

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## Abstract Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that the activity and expression of Na^+^