Chemotaxis in yersinia arthritis HLA-B27 positive neutrophils show high stimulated motility in vitro
✍ Scribed by Marjatta Leirisalo; Heikki Repo; Anja Tiilikainen; Timo U. Kosunen; Ossi Laitinen
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 660 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Chemotaxis, chemokinesis, and spontaneous locomotion of polymorphonuclear leukocytes (PMNs) of yersinia arthritis (YA) patients and healthy subjects with or without HLA‐B27 were studied by agarose assay and membrane filter technique. HLA‐B27 positive healthy control subjects and yersinia patients showed significantly higher response to chemotactic stimulus than HLA‐B27 negative controls. Consequently, the high response was associated with HLA‐B27 irrespective of YA. The high responder PMNs may contribute to the more severe inflammatory symptoms in YA patients with HLA‐B27.