✦ LIBER ✦

Chemotaxis: Basic aspects of methodology, mechanisms and pathology

✍ Scribed by B. M. Czarnetzki; E. Kownatzki; M. Dierich; P. C. Frei

Publisher: Springer-Verlag
Year: 1983
Tongue: English
Weight: 669 KB
Volume: 275
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00417333

No coin nor oath required. For personal study only.

✦ Synopsis

This review is an attempt to discuss the basic conceptual tools that are a prerequisite for any clinical study of chemotactic defects. They include familiarity with definitions of common terms and with the merits and drawbacks of the several possible in vivo and in vitro assay methods. Cellular mechanisms involved in locomotion are complex. They include basic requirements for cell metabolism as well as receptor recognition, attachment to surfaces and contraction of the cytoskeleton of the cell. Of the many chemotactic factors reported, few are well characterized and universally agreed upon. Similarly, with the use of more stringent criteria, a number of clinical defects of chemotaxis have proven transitory or even artifactual.

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