Chemoselective three-component coupling via a tandem Pd-catalyzed boron-Heck and Suzuki reactions

✍ Scribed by Justin O’Neill; Kyung Soo Yoo; Kyung Woon Jung

• Book ID: 104095925
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 235 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.10.039

✦ Synopsis

Reported herein is a new approach to prepare biaryl derivatives via a tandem Pd catalyzed boron-Heck and Suzuki reaction. This one-pot tandem process avoided purification or addition of extra catalyst between steps. The resulting biaryl compounds can be prepared with substrate variability in good to moderate yields.