✦ LIBER ✦
Chemoselective reduction of prostaglandin intermediates by liquid-phase hydrogen transfer on Pt–Sn/MCM-41 catalysts
✍ Scribed by S Coman; F Cocu; V.I Parvulescu; D De Vos; P.A Jacobs
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 230 KB
- Volume
- 44-45
- Category
- Article
- ISSN
- 1387-1811
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✦ Synopsis
Pt±Sn/MCM-41 reduction catalysts were prepared by a two-step impregnation procedure. The eect of the Sn content was evaluated in the liquid-phase hydrogen transfer reduction of an enone prostaglandin intermediate. Results indicate that up to a Sn/Pt atomic ratio of 3.3 increasing amounts of Sn favor the formation of the allylic alcohol. The reaction also displays moderate diastereoselectivity. On the other hand, the Pt/MCM-41 catalyst produces the saturated ketone as the main reaction product.