Chemoselective Reduction of Isatin-Derived Electron-Deficient Alkenes Using Alkylphosphanes as Reduction Reagents

✍ Scribed by Shu-Hua Cao; Xiu-Chun Zhang; Yin Wei; Min Shi

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 158 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201100017

✦ Synopsis

Abstract

Under mild reaction conditions, the C=C double bond inisatin‐derived electron‐deficient alkenes has been exclusively reduced in the presence of alkylphosphanes and water to afford the corresponding reduction products in good to excellent yields. A plausible mechanism is proposed on the basis of deuterium‐labeling experiments.