Chemoselective reduction of carbonyl compounds with borohydride exchange resin in alcoholic solvents

✍ Scribed by Nung Min Yoon; Kyoung Bae Park; Young Soo Gyoung

• Publisher: Elsevier Science
• Year: 1983
• Tongue: French
• Weight: 240 KB
• Volume: 24
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87870-3

✦ Synopsis

Borohydride exchange resin exhibited a high chemoselectivity not only *between aidehyde and ketone but also between aldehydes and between ketones. Polymer-supported reagents have gained in popularity in the last ten to fifteen years, and have already found wide applications in organic and inorganic chemistry, biochemistry and biologyI. Among these, borohydride exc'nange resin (BER) was first reported in 1977 by Gibson and Baily 2a and has been used in solvent purification, generation of volatile metal hydrides and reductions of metal ions and some aldehydes 2b . Now, we wish to report that BER shows high chemoselectivity in the reduction of car-bony1 compounds in alco'nolic solvents.