Chemoselective oxidation of primary alcohols to aldehydes with Gluconobacter oxydans

✍ Scribed by Raffaella Villa; Andrea Romano; Raffaella Gandolfi; José V. Sinisterra Gago; Francesco Molinari

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 110 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01221-2

✦ Synopsis

The production of aliphatic and aromatic aldehydes by oxidation of primary alcohols was achieved with Gluconobacter oxydans DSM 2343. The biotransformation was optimised studying the oxidation of 2-phenyl-1-ethanol to 2-phenylacetaldehyde. A high molar conversion (95% chromatographic conversion, 83% of isolated yield) was obtained using cells grown on glycerol as the main carbon source and directly used in the cultural medium after 24 h at 28°C, pH 4.5 and 5 g L -1 substrate concentration. The conversion of structurally different primary alcohols was performed under these conditions allowing the chemoselective production of aldehydes, sometimes with very good yields.