Chemoselective one-pot reductive deamination of aryl amines

✍ Scribed by Otto J Geoffroy; Thomas A Morinelli; G.Patrick Meier

• Book ID: 104231088
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 58 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01027-9

✦ Synopsis

A one-pot deamination of a wide variety of substituted anilines is described. The process involves a diazotizationdediazotization utilizing acetic acid, sodium nitrite, and sodium bisulfite-inexpensive, 'green' reagents. The process occurs quickly under mild conditions, tolerates sensitive functionality, and gives products in modest-to-good yields (16-88%).