Chemoselective deprotection of primary tert-butyldimethylsilyl ethers on carbohydrate molecules in the presence of secondary silyl ethers

✍ Scribed by Ming-Yi Chen; Kuo-Cheng Lu; Adam Shih-Yuan Lee; Chun-Cheng Lin

• Book ID: 104250808
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 158 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00385-4

✦ Synopsis

The primary silyl ethers of TBDMS-protected saccharides were regioselectively cleaved in excellent yields (71-95%) by treating the silyl ethers with a catalytic amount of CBr 4 in methanol under photochemical reaction conditions.