Chemoselective Amination of 5-Bromo-2-chloro-3-fluoropyridine.
✍ Scribed by Bryan W. Stroup; Paul V. Szklennik; Cornelia J. Forster; Michael H. Serrano-Wu
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 39 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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The asymmetric unit of the title compound, C 17 H 13 ClFNO 4 , contains two independent molecules. The dihedral angles between the pyridine and benzene rings are 83.3 (2) and 69.7 (1) in the two molecules. In the crystal structure, intermolecular C-HÁ Á ÁN and C-HÁ Á ÁF hydrogen bonds link the molec
BrCl 2 I, crystallizes in space group P2 1 /c with two molecules in the asymmetric unit. The molecules stack in two different directions, with their plane normals approximately parallel to [110] and [110]. The molecules of the asymmetric unit are held together by %±% interactions.
The title compound, C 18 H 15 BrClN 3 O 2 , was obtained by reacting 3-bromo-5-chlorosalicylic aldehyde and 4-aminoantipyrine. The structure displays a trans configuration about the imine C N double bond. The N atom is also involved in an intramolecular O-HÁ Á ÁN hydrogen bond, which stabilizes the
## Abstract The reaction of 3‐bromo‐2‐ethoxy‐1,5‐naphthyridine with KNH~2~/NH~3~ was reinvestigated. The procedure, described in the literature for the preparation of the title compound does not lead to this compound but to the isomeric 3‐bromo‐1‐ethyl‐1,5‐naphthyridin‐2(1__H__)‐one. Reaction of th