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Chemoprotection by 9-aminoacridine derivatives against the cytotoxicity of topoisomerase II-directed drugs

✍ Scribed by Finlay, Graeme J.; Wilson, William R.; Baguley, Bruce C.


Book ID
122068105
Publisher
Elsevier Science
Year
1989
Weight
837 KB
Volume
25
Category
Article
ISSN
0277-5379

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## Background Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA represents a novel form of DNA damage to cells. In this report, we characterise t