Chemometric Studies on the Bactericidal Activity of Quinolones via an Extended VolSurf Approach
β Scribed by Cianchetta, Giovanni; Mannhold, Raimund; Cruciani, Gabriele; Baroni, Massimo; Cecchetti, Violetta
- Book ID
- 127293247
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 191 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
An improved route to coenzyme Q 10 (1) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 -mediated oxidation of the protected isoprenylhydroquinone 3 into the (E)-allyl alcohol 5 without the formation of undesired stereoisomer and the one-p
An efficient and stereoselective approach to the synthesis of coenzyme Q 10 is described (Scheme). The MeOCH 2 -protected p-hydroquinone 4 containing the C 5 (E)-allyl (tert-butyl)dimethylsilyl ether moiety was obtained via a halogen -lithium exchange of the MeOCH 2 -proctected 2-bromo-5,6dimethoxy-