Chemokines in rheumatoid arthritis: novel, potential therapeutic targets of the CCR2 chemokine receptor signaling pathway
β Scribed by K Matsushima, Y Terashima, M Haino
- Book ID
- 120708093
- Publisher
- BioMed Central
- Year
- 2003
- Tongue
- English
- Weight
- 554 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1478-6354
- DOI
- 10.1186/ar832
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## Abstract ## Objective Rheumatoid arthritis (RA) is a chronic inflammatory condition characterized by a cellular influx and destruction of the joint architecture. Chemokines characteristically regulate leukocyte recruitment and activation. Chemokine (CC motif) receptorβlike 2 (CCRL2) is an orpha
## Abstract Subchondral bone remodeling in osteoarthritis (OA) and rheumatoid arthritis (RA) is mainly characterized by the formation of osteophytes/fibrosis and by the presence of infiltrating cells associated to bone resorption. In this study we analyzed CC (cysteine cysteine motif) chemokine lig