## Abstract The chemokine receptor CXCR4 possesses multiple critical functions in normal and pathologic physiology. CXCR4 is a Gβproteinβcoupled receptor that transduces signals of its endogenous ligand, the chemokine CXCL12 (stromal cellβderived factorβ1, SDFβ1). The interaction between CXCL12 and
β¦ LIBER β¦
Chemokine receptor CXCR4 as a therapeutic target for neuroectodermal tumors
β Scribed by Hyunsuk Shim; Shinya Oishi; Nobutaka Fujii
- Book ID
- 113900389
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 513 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1044-579X
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Background and Objectives: Using the technique of differential hybridization of Atlas TM Human cDNA expression arrays, we previously reported the isolation of a G protein coupled receptor, CXCR-4, which is overexpressed in glioblastoma multiforme tumor tissue (GMTT) compared to normal brain tissue (