𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chemokine Receptor Antagonists

✍ Scribed by Richard Horuk; Howard P. Ng

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
112 KB
Volume
20
Category
Article
ISSN
0198-6325

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✦ Synopsis

Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. Chemokines appear to be involved in a variety of proinflammatory and autoimmune diseases and this makes them and their receptors very attractive therapeutic targets. This review highlights current efforts toward obtaining highly specific chemokine receptor antogonists and discusses their chemistry and potential role as disease modifiers.

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## Abstract The chemokine receptor CXCR4 possesses multiple critical functions in normal and pathologic physiology. CXCR4 is a G‐protein‐coupled receptor that transduces signals of its endogenous ligand, the chemokine CXCL12 (stromal cell‐derived factor‐1, SDF‐1). The interaction between CXCL12 and