Chemoenzymic synthesis of the GM3-oligosaccharide [NeuNAcα(2–3)Galβ(1–4)Glc] on a water-soluble polymer support
✍ Scribed by Alexandra Tuchinsky; Uri Zehavi
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 164 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1381-5148
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## Abstract Three trisaccharide derivatives of the type β‐D‐Hex__p__‐(1 → 4)‐β‐D‐Glc__p__NAc(1 → 2)‐α‐D‐Man__p__‐(1 → O)(CH~2~)~7~CH~3~ have been synthesized, with Hex being either glucose (15), 4‐deoxy‐4‐fluorogalactose (20), or 4‐deoxygalactose (27). These trisaccharides have been designed for th
Synthesis of Protected Hexp-(1 → 4)-β-D-GlcpNAc-(1 → 2)-α-D-Manp-(1 → O)(CH2)7CH3 Sequences (Hex: β-D-Glc, 4-deoxy-4fluoro-β-D-Gal, or 4-deoxy-β-D-Gal) Using a Glc-GlcNPhth Donor, Eventually Fluorinated or Deoxygenated at the Oligosaccharide Level. -The title trisaccharide derivatives are prepared