Chemoenzymatic Synthesis of Spinosyn A
β Scribed by Kim, Hak Joong; Choi, Sei-hyun; Jeon, Byung-sun; Kim, Namho; Pongdee, Rongson; Wu, Qingquan; Liu, Hung-wen
- Book ID
- 126681306
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 624 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
The title alkaloid has been synthesized in eight operations from dibromobenzene and ovanillin, via enzymatic oxidation of the former compound, Suzuki coupling and a Bisehler-Napieralski type cyclization as the key transformations.
## Abstract A polymeric aminoglycoside was prepared by a facile chemoenzymatic reaction. Bocβprotected aminoglycoside, amikacin, was chemoselectively esterified with divinyl sebacate at a hydroxyl group in the C6β³ position by protease from __Bacillus subtilis__. The resulting 3,6β²,3β³,4β΄βtetraβ__N__