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Chemoenzymatic Synthesis of (S)-Hexafluoroleucine and (S)-Tetrafluoroleucine

✍ Scribed by Chiu, Hsien-Po; Cheng, Richard P.


Book ID
111961417
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
75 KB
Volume
9
Category
Article
ISSN
1523-7060

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## Abstract (__S__)‐5,5,5,5β€²,5β€²,5′‐Hexafluoroleucine ((__S__)‐13) of 81 % ee is prepared from hexafluoroacetone (l) and ethyl bromopyruvate (= ethyl 2‐oxopropanoate) in 7 steps with an overall yield of 18% (__Schemes 1__ and __2__). Key step in this sequence is the highly enantioselective reduction