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Chemoenzymatic Synthesis of (Protected) Psymberic Acid

✍ Scribed by Jörg Pietruszka; Robert Christian Simon

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
318 KB
Volume
2009
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Two alternative approaches to the side‐chain of psymberin (1), psymberic acid (5), have been developed starting from either racemic or enantiopure acetal 6. A five‐step chemoenzymatic route provided the PMB‐protected acid (S,S)‐16 required for the coupling that should ultimately lead to the natural product 1. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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