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Chemoenzymatic synthesis of Galα1-3Gal, Galα1-3Galβ1-4GlcNAc and their PEG-conjugates.

✍ Scribed by Ichiro Matsuo; Hiroshi Fujimoto; Megumi Isomura; Katsumi Ajisaka

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
196 KB
Volume
7
Category
Article
ISSN
0960-894X

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✦ Synopsis

Galc~l-3Gal-pNP was prepared enzymatically from Gal-pNP using et-galactosidase from coffee beans. PEG was attached after the reduction of nitro group into amino group to give Galal-3GaI-PEG conjugate. After removing the pNP group in Galctl.-3Gal-pNP, the obtained disaccharide was used for the synthesis of Galct l-3Gal[31-4GlcNAc and corresponding trisaccharide-PEG conjugate.

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