Chemoenzymatic synthesis of chiral enones from aromatic compounds
✍ Scribed by Valeria Schapiro; Gabriel Cavalli; Gustavo A. Seoane; Ricardo Faccio; Alvaro W. Mombrú
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 219 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0957-4166
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✦ Synopsis
A series of chiral enones was successfully synthesized from chemoenzymatically produced chiral diols. These chiral enones are highly functionalized synthons, which can be used in the total synthesis of natural products such as forskolin and avermectins.
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A chemoenzymatic approach was developed to prepare sucrose-containing aromatic polymers. The protease from Bacillus licheniformis catalyzed the transesterification of sucrose with a diester of terephthalic acid in pyridine to give the mono-and diester products. At 45°C, >70% of sucrose was consumed
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