Chemoenzymatic preparation of 4-O-acetyl sialic acid derivative
✍ Scribed by Tzenge-Lien Shih; Mou-Chi Cheng; Shih-Hsiung Wu
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 48 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
4-O-Acetyl sialic acid derivative could be easily prepared from the hydrolysis of 1 by lipase OF via the migration of acetyl groups.
📜 SIMILAR VOLUMES
Various 9-0-acyl derivatives of N-acetyl-and N-glycoloyl-neuraminic acid, and O-(5-acetamido-3,5-dideoxy-D-glycero-c-and -/3-D-gulucto-2-nonulopyranosylonic acid)-(2~6)-O-~-D-galactopyranosyl-(1~4)-D-glucopyranose were regioselectively synthesized by use of ortho esters. In addition, 5-acetamido-4-O
The presence of mono-, di-, and tri-O-acetylated sialic acids on human cells was demonstrated by using radiochromatographic and chemical techniques. Human melanoma cells and fresh colon tissue were biosynthetically labeled with 6- (3H) glucosamine. Radiolabeled sialic acids were hydrolytically remov
## Abstract Two new fluorescent regioselective __O__‐acetylated __N__‐acetylneuraminic acid (Neu5Ac) thioketosides, 2α‐[4‐(dansylamino)phenylthio]‐7,8,9‐tri‐__O__‐acetyl‐__N__‐acetylneuraminic acid {2α‐[4‐(dansylamino)phenylthio]‐Neu5,7,8,9Ac~4~} (3) and 2α‐[4‐(dansylamino)phenylthio]‐4‐__O__‐acety