Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines.

✍ Scribed by Jens Paetzold; Jan E. Baeckvall

• Publisher: John Wiley and Sons
• Year: 2006
• Weight: 26 KB
• Volume: 37
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.200618031

✦ Synopsis

Biochemical syntheses O 0035

Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines. -A variety of racemic unfunctionalized primary amines is transformed into optically pure amides in high yield and enantiomeric excess by use of Novozym 435 in the presence of racemization catalyst (I). Surprisingly, when substoichiometric amounts of Na2CO3 are added, the dynamic kinetic resolution process is more efficient. -(PAETZOLD, J.;