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Chemo-enzymatic synthesis of tripeptide RGD diamide in organic solvents

โœ Scribed by Yi-Bing Huang; Yu-Peng Xiao; Hua Wang; Rui-Zhen Hou; Na Zhang; Xiao-Xia Wu; Li Xu; Xue-Zhong Zhang

Book ID
118471220
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
301 KB
Volume
116
Category
Article
ISSN
0168-1656

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The enzymatic synthesis of the tripeptide derivative Z-Gly-Trp-Met-OEt is reported. This tripeptide is a fragment of the cholecystokinin C-terminal octapeptide CCK-8. Studies on the a-chymotrypsin catalyzed coupling reaction between Z-Gly-Trp-R, and Met-R, have focused on low water content media, us