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Chemo-enzymatic synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate

✍ Scribed by Paola D’Arrigo; Giuseppe Pedrocchi-Fantoni; Stefano Servi


Book ID
108284588
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
345 KB
Volume
21
Category
Article
ISSN
0957-4166

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Optically pure Ethyl (R)-2-hydroxy-4-phenylbutyrate has been synthesized stereoselectively in 24% overall yield. The recent discovery of potent inhibitors of angiotensin-converting enzyme (ACE) which incorporate the ethyl N-substituted-(S)-2-amino-4-phenylbutyrate moiety as a comnon structural eleme