AbstractÐA new technical synthesis to produce ethyl (R)-2-hydroxy-4-phenylbutyrate (5), an important intermediate for several ACE inhibitors with .99% ee in an over-all yield of 50±60% is described starting from acetophenone and diethyl oxalate. Key step is the chemoand enantioselective hydrogenatio
✦ LIBER ✦
Chemo-enzymatic synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate
✍ Scribed by Paola D’Arrigo; Giuseppe Pedrocchi-Fantoni; Stefano Servi
- Book ID
- 108284588
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 345 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0957-4166
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