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Chemo- and regioselective ethynylation of 4,5,6,7-tetrahydroindoles with ethyl 3-halo-2-propynoates

✍ Scribed by Boris A. Trofimov; Lyubov’ N. Sobenina; Zinaida V. Stepanova; Ol’ga V. Petrova; Igor’ A. Ushakov; Al’bina I. Mikhaleva


Book ID
108284958
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
128 KB
Volume
49
Category
Article
ISSN
0040-4039

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Condensation of 2-amino-3-cyano-4,5,6,7-
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Depending on conditions, the condensation of 2-amino-3-cyano-4,5,6,7-tetrahydroindole with 8-dicarbonyl compounds leads to 2-methyl-4-oxo-or 4-methyl-2-oxo-10-cyano-6,7,8,9tetrahydropyrimido[l,2-a]indoles via the intermediate compounds: 2-(3-ethoxy-carbonylprop-2-en-2-yl amino) and 2- (l,3-dioxobuty