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Chemistry of nitrosoureas. Intermediacy of 4,5-dihydro-1,2,3-oxadiazole in 1,3-bis(2-chloroethyl)-1-nitrosourea decomposition

โœ Scribed by Brundrett, Robert B.


Book ID
125544502
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
396 KB
Volume
23
Category
Article
ISSN
0022-2623

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Physiologic disposition of 1-(2-chloroet
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The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity