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Chemistry of Ginkgolides, VII. Preparation and Crystal Structure Analysis of a Secondary Ozonide from Ginkgolide A

✍ Scribed by Weinges, Klaus ;Schick, Hartmut ;Pritzkow, Hans

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
322 KB
Volume
1997
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

By hydrogenation of 3,14‐didehydro‐10‐hydroxyginkgolide (3,14‐anhydroginkgolide A, 1) the 3,14‐didehydro‐10‐hydroxyginkgolide‐15‐acid (2) was obtained. Reaction with diazomethane led to the methyl ester 2a, which was transformed into its MOM derivative 2b. Ozonolysis of 2b gave a stable secondary ozonide 3 and 10‐methoxymethoxy‐3‐oxo‐14,15,16‐trinorginkgolide (4).

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Chemistry of the Ginkgolides, VIII – Syn
Chemistry of the Ginkgolides, VIII – Synthesis and Crystal Structure of a Dimeric 14,15,16-Trinorginkgolide Derivative
✍ Weinges, Klaus ;Schick, Hartmut ;Irngartinger, Hermann ;Oeser, Thomas 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB

## Abstract Treatment of the enol acetate 3‐acetoxy‐10‐methoxy‐methoxy‐2,3‐didehydro‐14,15,16‐trinorginkgolide^[2^] (2) with potassium osmate/__N__‐methylmorpholine __N__‐oxide in acetone/acetic acid solution did not yield the expected 2‐hydroxy‐3‐oxo derivative 3, but the dimeric ginkgolide (2__S_