Chemistry of fluorinated enamines. Novel reaction of trifluoromethylated enamine with grignard reagents
β Scribed by Hee Moon Park; Tomonori Uegaki; Tsutomu Konno; Takashi Ishihara; Hiroki Yamanaka
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 238 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Trifluoromethylated enamine,3,3,
dimethylamine (1), readily reacted with a variety of Grignard reagents 2 at room temperature to afford the trifluorovinyl compounds 3 in good yields.
π SIMILAR VOLUMES
The r~glion of allylindium reagents with oert;fin nitriles 1 having another el~'tron withdrawing group at the a-position aliiwds the correslxmding allylation-enamination products 2 in high to good yields.
## Abstract Reaction of cyclohexanone enamines with Ξ±βchloroacrylonitrile and methyl Ξ±βchloroacrylate in polar solvents leads to hexahydroindolium salts of type 3. In ether solution at low temperature cyclobutanes, 9, are produced.