Chemistry of Epoxysulfones: A New Route to Polyhydroxylated Pyrrolidines.
β Scribed by David Diez; M. Templo Beneitez; M. J. Gil; R. F. Moro; Isidro S. Marcos; N. M. Garrido; P. Basabe; Julio G. Urones
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 28 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Starting from the (R)-(-)-phenylglycinol derivative (I), the stereoselective synthesis of polyhydroxylated pyrrolidines [cf. (VIII)] and the indolizidine (XII) is based on the diastereoselective condensation of the chiral silyloxypyrrole (III) with aldehydes (IV). The preparation of the indolizidine
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## Abstract The diastereofacial selection in addition reactions to biased rigid systems can be modulated by the action of Lewis acids. As an example, the stereoselectivity of the nucleophilic addition of vinyl magnesium bromide (VMB) to cyclic nitrones in the presence of diethylaluminum chloride (D