Chemistry of acetylenic ethers. Part 88: Synthesis of β-hydroxy-alkynes, substituted at the α-carbon atom

Carbon-carbon bond formation by the reac

Carbon-carbon bond formation by the reaction of organolithiums with α-lithiated cyclic enol ethers. Stereoselective synthesis of β- and γ-hydroxy di- and tri-substituted alkenes

✍ Thinh Nguyen; Ei-ichi Negishi 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 227 KB

su?n?M?y a-Ltth~anon of dthydrofuran, benzofuran, and dlhydropyran followed by treatment with vanous organohthtums stereoselecnvely produces m gwd ytelds the conespondmg rmg-opened Q-alkenylhthtums. t e , (E)-B(or y)-hydroxy-to-alkenyl-co-hthtoalkenes, the hthtum atom of which can be readtly replace