Chemische Modifikation von Kanamycin A Derivate mit 4,5-Doppelbindung im Kanosamin-Teil

✍ Scribed by Albert, Rainer ;Dax, Karl ;Gassner, Norbert A. ;Stütz, Arnold E. ;Weidmann, Hans

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 300 KB
• Volume: 1985
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.198519850327

✦ Synopsis

Chemical Modification of Kanamycin A. – Derivatives Containing a 4,5‐Double Bond in the Kanosamine Part

Oxidation of the primary alcohol group in the kanamycin A derivative 2b with simultaneous β‐elimination gave the α,β‐unsaturated aldehyde 3a of which the derivatives 3b – e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4 ‚‐deoxy‐5’︁‐epi‐kanamycin A derivatives.