β-Enaminoesters as building blocks in he
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Ayman W. Erian
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Article
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1999
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John Wiley and Sons
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English
⚖ 60 KB
Pyrimethamine 1 is a folic acid reductase inhibitor. In this molecule the ring nitrogen is flanked by two functional groups, which is essential to the biological activity of pyrimethamine. Also, a plethora of aminopterin 2 and 2,4-diamino-6-substituted quinazoline antifolates 3 exhibit strong antima