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ChemInform Abstract: β-Enaminoesters as Building Blocks in Heterocyclic Synthesis. A Novel Synthesis of Fused Azines by Using Blaise Reaction as a Key Step.

✍ Scribed by Ayman W. Erian


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
30
Category
Article
ISSN
0931-7597

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Pyrimethamine 1 is a folic acid reductase inhibitor. In this molecule the ring nitrogen is flanked by two functional groups, which is essential to the biological activity of pyrimethamine. Also, a plethora of aminopterin 2 and 2,4-diamino-6-substituted quinazoline antifolates 3 exhibit strong antima