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ChemInform Abstract: α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters.

✍ Scribed by Takuya Hashimoto; Kazuki Sakata; Keiji Maruoka

Publisher
John Wiley and Sons
Year
2009
Weight
33 KB
Volume
40
Category
Article
ISSN
0931-7597

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📜 SIMILAR VOLUMES

α-Chiral Acetylenes Having an All-Carbon
α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters
✍ Takuya Hashimoto; Kazuki Sakata; Keiji Maruoka 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB

## Abstract **Ein mehrphasiger Prozess**: Untersuchungen der Titelreaktion ergaben, dass sie als basenvermittelte Isomerisierung zu Allenylester und anschließende phasentransferkatalysierte Alkylierung an der α‐Position des Esters verläuft (siehe Schema).magnified image

α-Chiral Acetylenes Having an All-Carbon
α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters
✍ Takuya Hashimoto; Kazuki Sakata; Keiji Maruoka 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB

## Abstract **Going through the phases**: The title reaction was found to proceed by an initial base‐mediated isomerization to allenyl esters and subsequent phase transfer catalyzed alkylation at the α position of the ester (see scheme).magnified image