✦ LIBER ✦
ChemInform Abstract: Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407.
✍ Scribed by J. HUTTON; A. D. JONES; S. A. LEE; D. M. G. MARTIN; B. R. MEYRICK; I. PATEL; R. F. PEARDON; L. POWELL
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407.
-The synthesis of the title compound (IX) is achieved via a convenient method to the thiophene (III) by Ti-mediated addition of the ketone ( II) to 3-bromothiophene and efficient formation of the thiol (VI). -(HUTTON, J.;