ChemInform Abstract: Unusual Mechanistic Pathway for the Synthesis of Novel Spiro-oxindoles via 3-Phenyl-5-isoxazolone Ring Cleavage by Secondary Amino Acids.

Unusual mechanistic pathway for the synt

Unusual mechanistic pathway for the synthesis of novel spiro-oxindoles via 3-phenyl-5-isoxazolone ring cleavage by secondary amino acids

✍ Neelakandan Vidhya Lakshmi; Yuvaraj Arun; Paramasivam T. Perumal 📂 Article 📅 2011 🏛 Elsevier Science 🌐 French ⚖ 682 KB

A new approach to synthesize a series of spiro-oxindole derivatives via a multicomponent reaction of isatin, 3-phenyl-5-isoxazolone, and sarcosine or L-proline which play a dual role of base and nucleophile in methanol under reflux condition is reported. Also spiroindan-1,3-diones were synthesized f