ChemInform Abstract: Trifluoromethylation of Aromatic Isoxazoles: Regio- and Diastereoselective Route to 5-Trifluoromethyl-2-isoxazolines.

✍ Scribed by Hiroyuki Kawai; Kentaro Tachi; Etsuko Tokunaga; Motoo Shiro; Norio Shibata

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 30 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201202133

✦ Synopsis

Abstract

The activation of aromatic, heteroaromatic, or styryl isoxazoles such as (I) or (V) with a nitro group at the 4‐position results in the first diastereoselective trifluoromethylation at the 5‐position by nucleophilic addition of Tms‐CF~3~.