ChemInform Abstract: Total Synthesis of (+)-Tautomycin.
β Scribed by S. SHIMIZU; S. NAKAMURA; M. NAKADA; M. SHIBASAKI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Total Synthesis of (+)-Tautomycin.
-A convergent stereocontrolled synthesis of tautomycin (I), a specific inhibitor of protein serine/threonine phosphatases, is achieved.
π SIMILAR VOLUMES
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Total Synthesis of (Β±)-Taxusin. -The synthesis of the title compound (VI) starting from (I) is highlighted by 1.) remarkably effective eight-membered B ring cyclization leading to the C ring allyl ester-type tricyclic taxane skeleton(III) with the desired B ring conformation and C-9/C-10 stereochem