ChemInform Abstract: Total Synthesis of Antillatoxin, an Ichthyotoxic Cyclic Lipopeptide, Having the Proposed Structure. What Is the Real Structure of Antillatoxin?

✍ Scribed by Fumiaki Yokokawa; Takayuki Shioiri

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199920169

✦ Synopsis

Total Synthesis of Antillatoxin, an Ichthyotoxic Cyclic Lipopeptide, Having the Proposed Structure. What Is the Real Structure of Antillatoxin? -The synthesis of the peptide (VIII) is achieved via condensation of the ester (V) with the tripeptide (VI) and subsequent macrocyclization. Spectroscopic comparison indicates that natural antillatoxin does not adopt the proposed structure (VIII) but must be a stereoisomer. -(YOKOKAWA,