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ChemInform Abstract: Total Synthesis of 10-Deoxymethynolide, the Aglycon of the Macrolide Antibiotic 10-Deoxymethymycin.

✍ Scribed by Ronaldo A. Pilli; Carlos Kleber Z. de Andrade; Carlos Roberto O. Souto; Armin de Meijere


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


Total Synthesis of 10-Deoxymethynolide, the Aglycon of the Macrolide Antibiotic 10-Deoxymethymycin.

-The title compound (XI) is prepared in 12% overall yield via a synthetic equivalent (VIII) of the Prelog-Djerassi lactonic acid and the construction of a 12-membered lactone through an intramolecular Nozaki-Hiyama-Kishi coupling reaction. -(PILLI,


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