𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Theoretical Calculations of β-Lactam Antibiotics. Part 7. Influence of the Solvent on the Basic Hydrolysis of the β-Lactam Ring.

✍ Scribed by J. FRAU; J. DONOSO; F. MUNOZ; F. GARCIA-BLANCO


Book ID
112033825
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Theoretical Calculations of β-Lactam Ant
✍ Juan Frau; Josefa Donoso; Francisco Muñoz; Francisco Gracia-Blanco 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 571 KB

We used semi-empirical and ab initio calculations to investigate the nucleophilic attack of the OHion on the 8-lactam carbonyl group. Both allowed us to detect reaction intermediates pertaining to proton-transfer reactions rather than the studied reaction. We also used the PM3 semi-empirical method

Theoretical calculations of β-lactam ant
✍ J. Frau; J. Donoso; F. Muñoz; F. García Blanco 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 697 KB

A comprehensive study on the gas-phase alkaline hydrolysis of cephalosporins by using the semiempirical AM1 method was carried out. Cephalothin was the model compound used on account of the presence of a good leaving group at C(3'). According to the results obtained, the hydrolysis process takes pla

Theoretical calculations of β-lactam ant
✍ J. Frau; J. Donoso; F. Muñoz; F. García Blanco 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 905 KB

Semiempirical AM1, MINDO/3, and MNDO methods have been used in the study of the alkaline hydrolysis of P-lactam antibiotics through a base-catalyzed, acyl-cleavage, bimolecular mechanism. In this work, the hydroxyl ion has been chosen as nucleophilic agent and the azetidin-2-one ring like a model of