ChemInform Abstract: The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors
✍ Scribed by Myung, Jayhyuk (author);Kim, Kyung Bo (author);Crews, Craig M. (author)
- Publisher
- Wiley
- Year
- 2010
- Weight
- 24 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and exampl
## Abstract The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin‐dependent apoptosis. Using pharmacological inhibitors an
## Abstract This article describes an undergraduate biochemistry laboratory investigating the ubiquitin‐proteasome pathway in yeast. In this exercise, the enzyme β‐galactosidase (β‐gal) is expressed in yeast under the control of a stress response promoter. Following exposure to heat stress to induc