ChemInform Abstract: The Synthesis of Ketomethylene Pseudopeptide Analogues of Dipeptide Aldehyde Inhibitors of Calpain.

✍ Scribed by Michael R. Angelastro; Angela L. Marquart; Shujaath Mehdi; Jack R. Koehl; Roy J. Vaz; Philippe Bey; Norton P. Peet

• Book ID: 101882014
• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199919227

✦ Synopsis

The Synthesis of Ketomethylene Pseudopeptide Analogues of Dipeptide Aldehyde Inhibitors of Calpain.

-Ketomethylene isosteres of Cbz-Val-Ala-H (VI) and Cbz-Val-Phe-H (IX) are synthesized via α-methyleneγ-butyrolactone (V) as key intermediate and their inhibition constants against chicken gizzard smooth muscle calpain are determined. -(ANGELASTRO,